还有两周就迎来2018年了,我们从今天开始对各个科研热点在2017的研究进展进行盘点,其实上次我们已经盘点过circRNA领域了:研究环状circRNA发5-10分的杂志,是不是很容易?,研究circRNA发10分以上的杂志,这三个思路你都知道吗?。好,废话不多说了,第一期我们来看lncRNA这个热点。
简单一点,2017年lncRNA研究一共发表接近2700篇文章,其中10分以上的杂志收录的文章有192篇(7.1%),5到10分范围收录的文章有660篇(24.4%),3-5分范围收录的有472篇(17.5%),剩下的3分以下的文章有1376篇(50.9%),也就说基本上3分以下的文章占了一半。
下面我们先看这192篇10分以上文章的情况。
我们先看杂志分布:
发表文章最多的前10个杂志分别是:
杂志数量影响因子Nucleic Acids Res3710.161Nat Commun1912.123Nat Chem Biol915.065Mol Cell914.713Hepatology913.246Genome Res811.385Nature740.137Nat Struct Mol Biol713.338Genome Biol710.862Circ Res713.965Nucleic Acids Res杂志和Nat Commun杂志遥遥领先,年文章量分别为1270和3534篇,Nucleic Acids Res杂志去年影响因子还是9.2,今年已经突破10分了,在37篇文章里面包括了11个好用的数据库:
CNS三大顶级期刊关于lncRNA的一共有19篇。咱们中国人的文章有49篇,有一些文章我们已经介绍过了:
lncRNA的这个机制一般只出高分文章(lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling.Nat Med. 2017 Nov;23(11):1331-1341.)
只做细胞机制实验,这篇文章是怎么发到10分的?(Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.Nucleic Acids Res. 2017 Sep 29;45(17):9947-9959.)
基金中标一年内发Hepatology,何祥火教授是如何做到的?(Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin-6/STAT3 signaling pathway.Hepatology. 2017 Jul 26.)
听说10分以上的杂志,NC灌水最容易?(The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways.Nat Commun. 2017 Jul 26;8(1):144.)
孙树汉最新的18分文章说了什么?(The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1.Nat Cell Biol. 2017 Jul;19(7):820-832.)
准备国自然基金,这篇文章给了很好的模板!(A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.Nat. Cell Biol.2017 Nov 29 ;19(12))
(2)接下来看一下研究方向与领域:
我们根据题目对各个方向进行统计,在这些研究里面,肿瘤相关的研究是最多的有29篇,如:
Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide;
The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element;
Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development;
Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression;
A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis;
m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program;
炎症、病毒和免疫相关的有9篇,如:
An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism.
Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity.
The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation.
心血管系统疾病相关的有8篇,如:
The long noncoding RNA Wisper controls cardiac fibrosis and remodeling.
Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury.
Inhibition of the Cardiac Fibroblast-Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic Dysfunction.
肝病相关的有6篇,如:
Linking long noncoding RNA to control bile acid signaling and cholestatic liver fibrosis.
H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of epithelial cell adhesion molecule.
The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways.
另外跟肌肉生长发育有关有5篇,如:
lncRNA-Encoded Polypeptide SPAR(s) with mTORC1 to Regulate Skeletal Muscle Regeneration.
Lnc-mg is a long non-coding RNA that promotes myogenesis.
mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.
Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD.
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